Front-loading Hedgehog

Mike GENE

The hypothesis of front-loading continues to gather traction.  Consider this description of the Hedgehog signaling pathway:

In a growing embryo, cells develop differently in the head or tail end of the embryo, the left or right, and other positions. They also form segments which develop into different body parts. The hedgehog signaling pathway gives cells this information that they need to make the embryo develop properly. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. When the pathway malfunctions, it can result in diseases like basal cell carcinoma. [1]

The hedgehog signaling pathway is one of the key regulators of animal development conserved from flies to humans. The pathway takes its name from its polypeptide ligand, an intercellular signaling molecule called Hedgehog (Hh) found in fruit flies of the genus Drosophila. Hh is one of Drosophila’s segment polarity gene products, involved in establishing the basis of the fly body plan. The molecule remains important during later stages of embryogenesis and metamorphosis.

So here we have a circuit that is essential to the development of metazoan body plans.  How in the world could we front-load this information into a single-celled organism?

Steve Fuller’s lecture on ID

Front-loading with Homeodomains by Mike Gene

 ”As the new data comes , undirected fabl of Darwinian evolution becomes more and more tricky misinformation of the materialism.This article belongs to my most favourite researcher, Mike Gene who works on directed evolutionary processes called front-loading. Here is the latest article on him. You had better visit his site ( the design matrix ) to learn more about the concept of fron t loading.”

Mike GENE

For years, I have been trying to flesh out the conceptualization of front-loading evolution at the origin of life. A working hypothesis has been that the first cells (uni-cellular life forms) were front-loaded with information that would facilitate the evolution of multi-cellular life. One possible candidate for such front-loaded ‘information’ would be the homeodomain proteins. These proteins play essential roles in metazoan development and are considered part of the developmental toolkit as outlined by biologist Sean Carroll.

A few months ago, a study was published that outlines data and arguments that perfectly resonate with my front-loading views. Let’s have a look.

The study is Homeodomain proteins belong to the ancestral molecular toolkit of Eukaryotes, published by French researchers, Romain Derelle, Philippe Lopez, Herve´ Le Guyader, and Michael Manuel. It was published in the June, 2007 issue of Evolution & Development (9:212–219). Feast your eyes on the abstract:

On ”A simpler Origin for Life”

Robert Shapiro is one of the greatest scientist on DNA chemistry. He has over 125 publications and many scientific articles and his last article entitled as ” A simpler Origin for Life” He amazingly describes why the Darwinian manner of evolution is invalid about explanining life on earth.He confessed that Darwinian scoptoma is totally improbable and impossible when we take mathematical probalities of origins of molecular life into consideration.He put forward polished claim called small molecules rooted back to Oparin, Russian scientist. He explained his theory with same intruments within the Darwinian toolbox.As everyone knows R.Dawkins loves to use those grammatical intruments when he tells his fairy tales about evolution.They are such as ; If…., may have, might have, colud have been, etc.. but R.Shapiro is maybe the one and only scientist ,being honest about Darwinian evolution from the materialist camp.His works lead us cross examining the facts  which science has discovered about molecular life and evolution within last decades.

Here is his latest article on Sciam